A fascinating find
A recent study from Monash University in Australia has revealed a surprising relationship that could change our understanding of antibiotic use and its association with asthma. This research, led by Professor Ben Marsland and published in the journal ‘Immunity’, has discovered a molecule called IPA, produced by certain bacteria in a healthy intestine, which is essential for long-term protection against this respiratory disease.
An innovative approach
The research team managed to isolate this molecule, which can become a simple treatment option, in the form of a nutritional supplement, for children at risk of developing asthma. Professor Marsland says these findings are crucial to understanding how frequent antibiotic use negatively affects the gut microbiota, which in turn increases the risk of allergies and asthma.
Alterations in the microbiota
Marsland explained that the decrease in the number of IPA-producing bacteria is a direct consequence of antibiotic treatment. “We know that early exposure to these medications alters the gut microbiota in a negative way. Doing so increases the risk of developing allergies and asthma in later life.”
Importance of the first years of life
The first years in an individual’s life are critical for the formation of a balanced intestinal microbiota. As Marsland explains, “this process is affected by various factors, such as diet, genetics and the environment. Babies who are at high risk of allergies and asthma usually show development of their intestinal microbiota that does not progress optimally.” .
Use of antibiotics and their effects
The use of antibiotics during the first year of life could have unintended consequences, such as the reduction of beneficial bacteria. Research shows that decreasing IPA levels is especially relevant at this stage, aligning with the maturation of lung cells, making this molecule a valuable candidate for preventing allergic inflammation in the airways.
Revealing experiments
The team used mice predisposed to developing asthma and observed that when these mice received antibiotics at an early age, they showed increased susceptibility to allergic inflammation caused by dust mites. This trend continued into adulthood, highlighting a long-lasting connection that persisted even after gut microbiome and IPA levels normalized.
Promising results
When these mice were given an IPA supplement from a young age, the researchers noted that they effectively recovered from dust mite-induced allergic inflammation in their airways, suggesting that this approach could be key to the management and preventing asthma in the future.