The link between microbiota, iron and cognition
An innovative study from the Girona Biomedical Research Institute (IDIBGI) has revealed a fascinating link between the intestinal microbiota, blood iron levels and cognition. This finding, based on a large study of more than a thousand individuals, sheds light on the influence of diet and intestinal microbiota on our mental health.
The role of ferritin
Researchers found that blood levels of ferritin, a protein that stores iron, are positively correlated with the brain’s executive function, responsible for crucial skills such as planning, inhibition, flexibility, verbal fluency and memory. These skills are essential for our daily activities.
The gut microbiota and executive function
The study also identified specific bacterial species in the gut microbiota that are inversely related to both blood ferritin levels and brain executive function. This suggests that the gut microbiota may play a role in modulating the effects of iron on cognition.
Metabolic pathways involved
At the molecular level, the researchers identified specific metabolic pathways that appear to influence the relationship between iron and cognition. These findings suggest that the gut microbiota could influence the effects of iron on cognition.
Implications for mental health
The researchers believe that this study opens new avenues for understanding the link between gut microbiota and brain health. If this link is understood, it could lead to the development of therapies for cognitive disorders based on modifying the gut microbiota through dietary changes.
The study was directed by Dr. Jordi Mayneris-Perxachs, researcher in the Nutrition, Eumetabolism and Health group of IDIBGI and CIBEROBN, and had the collaboration of researchers from the FISABIO Foundation – CIBERESP and the University of Lleida (UdL). – Lleida Biomedical Research Institute (IRBLleida).