A new discovery in melanoma research
Researchers at the Vall d’Hebron Research Institute have made an important finding that illuminates an unknown biological mechanism so far. The study reveals that exposure to ultraviolet radiation in newborns can trigger skin reactions, such as redness and blisters, with potentially serious consequences, including the possibility of developing melanoma later.
An unanswered riddle: from benign freckles to melanomas
One of the great mysteries in the field of melanoma is the transition of some benign freckles to malignant forms. Each year, approximately 150,000 new cases of melanoma in Europe are diagnosed, and this figure is expected to increase due to factors such as climate change. About 25% to 33% of benign spots can evolve into melanoma, but the causes of this evolution are still an enigma.
THE BRAFV600E GEN PAPER
The research has focused on the mutation of the BAFV600E gene, present in 80% of the freckles. This mutation initially promotes the growth of melanocytes, but in later phases it can inhibit proliferation. However, this same mutation is also in more than 50% of the melanomas diagnosed, which suggests a complex behavior that is not yet fully understood.
Activation of genetic mechanisms and their involvement
Researchers have found that intense exposure to UV radiation, combined with the activation of the BRAFV600E mutation, causes a reprogramming in genetic expression. This allows cancer cells to proliferate in an uncontrollability, which explains the possibility of developing melanomas without the visible presence of freckles or spots.
A NOVA DIANA THERAPEUTICS
Within this context, scientists have identified the UPP1 molecule as a therapeutic target potential. Its inhibition could reduce the viability of tumor cells, thus slowing down the melanoma. Although more research will be needed to validate this strategy in humans, the results open new avenues for the treatment of melanoma.
A promising futur in La Lluita against melanoma
Understanding the molecular processes that contribute to the appearance of melanoma is crucial. This research not only helps to decipher the mechanisms involved, but can also lead to more effective public health strategies to reduce the incidence of this disease. Science progresses, and every discovery brings us closer to the solution to combat melanoma.
